Olopatadine

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Composition and shape of issue
The preparation is available as a liquid intended for burying in the eye, transparent or pale yellow in a 5 ml bottle. The content of olopatadine in 1 ml solution is 1.11 mg. In addition to the main active ingredient, the medicinal product contains such auxiliary compounds as benzalconium chloride, sodium chloride, dynatrium phosphate dodecagirate, concentrated hydrochloric acid, sodium hydroxide (non-permanent component) and purified water. Olopatadine.

Pharmacological action
Olopatadine is called an anti-allergic, double-acting drug.
Firstly, it is an antihistamine drug, that is, the drug blocks H1-receptors that are in the eye cells, including conjunctival epithelial cells. These receptors are sensitive to histamine, a compound that plays a huge role in the development of allergic and inflammatory reactions of the body, and are found mainly in smooth muscle, central nervous system and endothelium. Olopatadine prevents inflammation by reducing swelling, itching and tears. Conjunctival cells also contain a type of epithelial cell, which produces compounds such as interleukins in response to histamine exposure. These substances also participate in the inflammatory response. The drug blocks their effect, providing a strong anti-inflammatory effect.
The advantage of this drug over other antihistamine eye drops is that it does not affect the histamine receptors located in the cells of the stomach and nervous system, and has no effect on muscarinic, serotonin and adrenergic receptors. This selectivity of action prevents unnecessary reactions from other organs and systems, significantly reducing the number of side effects.
Secondly, Olopatadine eye drops have an effect on fat cells. It prevents the release of histamine and other active substances involved in the inflammatory reaction. In addition, the drug is able to stabilize the membrane of these cells, also called labrocytes, preventing them from being destroyed. This is another of its differences from other antihistamine drugs, the side effect of which was lysis (destruction) of the fat cells.
In addition, in case of allergy there is a migration of blood cells (eosinophils) in the body, which subsequently contribute to the development of local inflammation. The drug suppresses this phenomenon, reducing the number of eosinophils and their pro-inflammatory effect.
Olopatadine eye drops, when used locally, are absorbed into the systemic blood flow only in small amounts and are removed from the body by kidneys, only partly subjected to changes and processing.


Indications .
Olopatadine is used in ophthalmological practice to treat allergic eye diseases such as:
allergic conjunctivitis of various etiologies (seasonal polynosis, large papillary, medicinal), including chronic forms;
allergic keratoconjunctivitis;
allergic reactions to contact lenses;
allergic reactions to infectious lesions and systemic diseases;
allergic blepharitis.
The drug helps to fight the effects of various allergens (house dust, pollen, cosmetics, etc.).
Contraindications
It is not recommended to take eye drops in case of individual intolerance to the active substance or one of the components of the preparation. There is no data on the use of the drug in children under three years of age, so the need for prescription at this age should be judged by the attending physician.
It is also unknown how the drug affects pregnant and lactating women and whether it has a teratogenic effect. However, in animal experiments, slow development of offspring was noted in those females who received Olopatadine. During pregnancy, eye drops will only be justified if there is an urgent need to treat eye disease, when the possibility of obtaining a therapeutic effect is higher than the risk of harm to the child.
It is not known whether the drug gets into breast milk when used topically, so the decision on the necessity of its prescription during lactation can only be made by the attending physician. https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/20688slr016_patanol_lbl.pdf
In addition, no data has yet been obtained on how the drug behaves when kidney or liver function is impaired. However, it is believed that the drops should not have a negative effect on the body in these pathologies.

 

Side effects
Redness, tears, burning and itching in the eyes are possible. These symptoms are temporary and there is no danger, so you can continue using the drug without fear.
Also in some cases, against the background of the use of the drug develops keratitis, irrite, pharyngitis, sinusitis, dizziness, “shroud” before the eyes, weakness, nausea and changes in taste.
Some side effects can cause benzalconium chloride, which is part of the drug. In addition to the fact that it may be attracted to the nylon.

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