Description of the drug Prometazine
Pharmacology: Pharmacological action – antihistamine, anti-allergic, sedative, hypnotic, antiemetic, local anesthetic, antipruritic. Competitively blocks H1-histamine receptors, has anti-exudative, anti-allergic, anti-inflammatory, local anesthetic effect.
Indications to the use of promethazine: Allergodermatosis, prurigo, eczema, exudative diathesis, urticaria, rash, etc. Cutaneous allergic reactions to drugs and chemicals, itching, allergic conjunctivitis, rhinitis, pollinosis, stings of wasps, bees, scorpions, bumblebees, serum disease, angioedema, false croup, asthmatic bronchitis, atopic bronchial asthma, anaphylactic and anaphylactoid reactions (in the complex therapy), rheumatism with a pronounced allergic component; Meniere’s syndrome, dizziness, nausea and vomiting, motion sickness syndrome; anxiety, neurosis and neurosis-like conditions, psychosis, insomnia, extrapyramidal disorders (against the background of taking neuroleptics), trigeminal neuralgia, migraine, chorea, hyperthermia; premedication and postoperative period (as a sedative, for artificial hibernation, potentiating anesthesia and local anesthesia), study of gastric secretion (when used as a stimulant of histamine secretion).
Contraindications: Hypersensitivity (including to other phenothiazines). phenothiazines), coma, alcohol intoxication, hepatic insufficiency, jaundice, prostatic hypertrophy, predisposition to urinary retention, stenosis of the bladder neck, closed-angle glaucoma, Ulcer disease with pyloroduodenal obstruction, lower respiratory tract diseases, epilepsy, sleep apnea syndrome, Ray syndrome, pregnancy, lactation, children (under 2 years) and elderly.
Administration during pregnancy and lactation: Contraindicated. Breast-feeding should be stopped during treatment.
Interaction: Increases the effects of analgesics, hypnotics, tranquilizers, neutroleptics, anesthetics, local anesthetics, m-cholinoblockers, hypotensive drugs (requires dose adjustment). Weakens the effect of amphetamine derivatives, m-cholinomimetics, anticholinesterase drugs, ephedrine, guanethidine, levodopa, dopamine. Barbiturates accelerate elimination and decrease activity. Beta-adrenoblockers increase (mutually) plasma concentrations (acute hypotension, arrhythmias, irreversible retinopathy, tardive dyskinesia are possible). It weakens the effect of bromocriptine and increases the serum concentration of prolactin. Tricyclic antidepressants and anticholinergic agents potentiate m-cholinoblocking activity, ethyl alcohol, clopheline, antiepileptic agents – CNS depression. MAO inhibitors (concomitant administration is not recommended) and phenothiazine derivatives increase the risk of hypotension and extrapyramidal disorders. Quinidine increases the possibility of cardiodepressive effects.